Aylin Paul, Bottle Alex, Jarman Brian, Elliott Paul
Dr Foster Unit at Imperial College London, Department of Epidemiology and Public Health, Imperial College School of Medicine, London W2 1PG.
BMJ. 2004 Oct 9;329(7470):825. doi: 10.1136/bmj.329.7470.825.
To describe trends in mortality of open cardiac surgery in children in Bristol and England since 1991.
Retrospective analysis of hospital episode statistics data.
All open cardiac surgery of children in England.
Patients younger than 16 undergoing open cardiac surgical procedures in England between April 1991 and March 2002. Three time periods were defined: epoch 3 (April 1991 to March 1995), epoch 5 (April 1996 to March 1999), epoch 6 (April 1999 to March 2002).
Mortality in hospital within 30 days of a cardiac procedure.
We identified 5221 open operations between April 1996 and March 2002 in children under 1 year and 6385 in children aged 1-15 years. Mortality for all centres combined fell from 12% in epoch 3 to 4% in epoch 6. Mortality in children under 1 year at Bristol fell from 29% (95% confidence interval 21% to 37%) in epoch 3 to 3% (1% to 6%) in epoch 6, below the national average. The reduction in mortality did not seem to be due to fewer high risk procedures or an increase in the numbers of low risk cases. Oxford had a significantly higher mortality than the national average in all three epochs (11% (5% to 18%) in epoch 6), which was not affected by adjusting for procedure or the inclusion of cases with missing outcomes.
At Bristol, mortality for open operations in children aged under 1 year has fallen markedly, to below the national average. Nationwide mortality has also fallen. Improved quality of care may account for the drop in mortality, through new technologies or improved perioperative and postoperative care, or both.
描述自1991年以来布里斯托尔及英格兰儿童心脏直视手术的死亡率趋势。
对医院病历统计数据进行回顾性分析。
英格兰所有儿童心脏直视手术。
1991年4月至2002年3月期间在英格兰接受心脏直视手术的16岁以下患者。定义了三个时间段:第3阶段(1991年4月至1995年3月)、第5阶段(1996年4月至1999年3月)、第6阶段(1999年4月至2002年3月)。
心脏手术后30天内的院内死亡率。
我们确定了1996年4月至2002年3月期间1岁以下儿童的5221例心脏直视手术以及1 - 15岁儿童的6385例手术。所有中心合并的死亡率从第3阶段的12%降至第6阶段的4%。布里斯托尔1岁以下儿童的死亡率从第3阶段的29%(95%置信区间21%至37%)降至第6阶段的3%(1%至6%),低于全国平均水平。死亡率的降低似乎并非由于高风险手术减少或低风险病例数量增加。在所有三个阶段,牛津的死亡率均显著高于全国平均水平(第6阶段为11%(5%至18%)),调整手术因素或纳入结局缺失的病例后,这一情况并未受到影响。
在布里斯托尔,1岁以下儿童心脏直视手术的死亡率显著下降,低于全国平均水平。全国范围内的死亡率也有所下降。护理质量的提高可能是死亡率下降的原因,这可能是通过新技术、改善围手术期和术后护理,或两者兼而有之实现的。