当将用1,2 - 二甲基肼处理的斯普拉格 - 道利大鼠用作结肠癌发生模型时耳部肿瘤的出现情况。

Appearance of ear tumors in Sprague-Dawley rats treated with 1,2-dimethylhydrazine when used as a model for colonic carcinogenesis.

作者信息

Viñas-Salas J, Fortuny J C, Panades J, Piñol C, Prim M, Fermiñan A, Corbella G, Calderó J, Egido R

机构信息

Department of Medicine and Surgery, Faculty of Medicine, Estudi General de Lleida, University of Barcelona, Catalonia, Spain.

出版信息

Carcinogenesis. 1992 Mar;13(3):493-5. doi: 10.1093/carcin/13.3.493.

DOI:10.1093/carcin/13.3.493

PMID:1547541

Abstract

One of the models of colon carcinogenesis in rats is produced by s.c. injections of 1,2-dimethylhydrazine (DMH). This specific colon carcinogen provokes other tumors in the rat, notably intestinal tumors. Ear tumors are just marginally mentioned in the literature. We have studied the appearance and histologic characteristics of ear tumors produced by 19 s.c. injections of 21 mg/kg of DMH in 18 Sprague-Dawley rats: 15 tumors appeared in 13 ears of 10 rats (55% of the animals). Simultaneously there were 23 colonic tumors: four (26.6%) of the tumors were carcinomas, 10 (66.6%) papillomas and one (6.6%) pseudoepitheliomatous hyperplasia. We conclude that ear tumors induced by DMH appear in 55% of the rats and that it is not possible to distinguish macroscopically in terms of size and aspect between benign and malignant lesions.

摘要

大鼠结肠癌发生的模型之一是通过皮下注射1,2 - 二甲基肼（DMH）建立的。这种特定的结肠致癌物会诱发大鼠的其他肿瘤，尤其是肠道肿瘤。耳部肿瘤在文献中仅被略微提及。我们研究了18只Sprague-Dawley大鼠皮下注射19次、每次21 mg/kg DMH后耳部肿瘤的出现情况和组织学特征：10只大鼠的13只耳朵出现了15个肿瘤（占动物总数的55%）。同时还出现了23个结肠肿瘤：其中4个（26.6%）为癌，10个（66.6%）为乳头状瘤，1个（6.6%）为假上皮瘤样增生。我们得出结论，DMH诱发的耳部肿瘤出现在55%的大鼠中，并且在大小和外观方面无法通过肉眼区分良性和恶性病变。