Kairisto V, Koskinen P, Mattila K, Puikkonen J, Virtanen A, Kantola I, Irjala K
Central Laboratory, University Central Hospital of Turku, Finland.
Clin Chem. 1992 Mar;38(3):416-20.
The urinary excretion of normetanephrine, metanephrine, and 3-methoxy-4-hydroxymandelic acid was quantified by HPLC in hypertensive patients who were being routinely investigated for the exclusion of pheochromocytoma. The data were used to calculate reference intervals for these analytes. Age- and sex-specific 95% reference intervals for 24-h urinary excretion were as follows (mumol/24 h): normetanephrine in men ages 16-35 years (n = 17) 0.7-3.4, in men older than 35 years (n = 121) 0.8-5.1, in women ages 16-35 years (n = 41) 0.5-2.1, and in women older than 35 years (n = 144) 0.6-3.3 mumol/24 h; metanephrine in men (n = 138) 0.3-2.0, and in women (n = 185) 0.2-1.3; and 3-methoxy-4-hydroxymandelic acid in men (n = 142) 10-54, and in women (n = 184) 9-38. Normetanephrine or metanephrine excretion rates or both exceeded the proposed reference intervals in seven of the eight patients with pheochromocytoma. Determination of 3-methoxy-4-hydroxymandelic acid excretion did not yield any additional diagnostic information.
采用高效液相色谱法（HPLC）对正在接受常规检查以排除嗜铬细胞瘤的高血压患者的去甲变肾上腺素、变肾上腺素和3-甲氧基-4-羟基扁桃酸的尿排泄量进行了定量分析。这些数据用于计算这些分析物的参考区间。24小时尿排泄的年龄和性别特异性95%参考区间如下（μmol/24小时）：16至35岁男性（n = 17）的去甲变肾上腺素为0.7 - 3.4，35岁以上男性（n = 121）为0.8 - 5.1，16至35岁女性（n = 41）为0.5 - 2.1，35岁以上女性（n = 144）为0.6 - 3.3 μmol/24小时；男性（n = 138）的变肾上腺素为0.3 - 2.0，女性（n = 185）为0.2 - 1.3；男性（n = 142）的3-甲氧基-4-羟基扁桃酸为10 - 54，女性（n = 184）为9 - 38。在8例嗜铬细胞瘤患者中，有7例患者的去甲变肾上腺素或变肾上腺素排泄率或两者均超过了建议的参考区间。3-甲氧基-4-羟基扁桃酸排泄量的测定未提供任何额外的诊断信息。
