Tsai Julia, Grutzendler Jaime, Duff Karen, Gan Wen-Biao
Molecular Neurobiology Program, Skirball Institute and Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA.
Nat Neurosci. 2004 Nov;7(11):1181-3. doi: 10.1038/nn1335. Epub 2004 Oct 10.
Amyloid plaques are a hallmark of Alzheimer disease, but their importance in its pathogenesis is controversial. By neuronal labeling and transcranial two-photon imaging, we show in a transgenic mouse model of Alzheimer disease that dendrites passing through or near fibrillar amyloid deposits undergo spine loss and shaft atrophy, and nearby axons develop large varicosities, together leading to neurite breakage and large-scale, permanent disruption of neuronal connections. Thus, fibrillar amyloid deposition is more detrimental to neuronal circuitry than previously thought, underscoring the importance of prevention and early clearance of plaques.
淀粉样斑块是阿尔茨海默病的一个标志，但其在发病机制中的重要性存在争议。通过神经元标记和经颅双光子成像，我们在阿尔茨海默病转基因小鼠模型中发现，穿过纤维状淀粉样沉积物或在其附近的树突会发生棘突丢失和轴突萎缩，附近的轴突会形成大的膨体，共同导致神经突断裂和神经元连接的大规模永久性破坏。因此，纤维状淀粉样沉积对神经回路的损害比以前认为的更大，这突出了预防和早期清除斑块的重要性。
