二硫代氨基甲酸盐铂（IV）和钯（II）配合物的三苯基膦加合物：光谱及体外研究
Triphenyl phosphine adducts of platinum(IV) and palladium(II) dithiocarbamates complexes: a spectral and in vitro study.
作者信息
Manav N, Mishra A K, Kaushik N K
机构信息
Department of Chemistry, University of Delhi, 110007, India.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2004 Nov;60(13):3087-92. doi: 10.1016/j.saa.2004.01.031.
Triphenyl phosphine adducts of dithiocarbamate complexes of platinum(IV) and palladium(II) of the type [Pt(L)2PPh3Cl2] and [Pd(L)2PPh3] [L: morpholine dithiocarbamate (L1), aniline dithiocarbamate (L2) and N-(methyl, cyclohexyl) dithiocarbamate (L3)] were prepared and characterized by elemental analysis, electronic, IR, 1H NMR and 13C NMR spectral studies. Thermal studies of the complexes were carried out. In vitro antitumor activity has been screened towards human adenocarcinoma cell lines and showed significant inhibition even at very low concentration.
制备了[Pt(L)₂PPh₃Cl₂]和[Pd(L)₂PPh₃]类型（L：吗啉二硫代氨基甲酸盐（L1）、苯胺二硫代氨基甲酸盐（L2）和N-(甲基,环己基)二硫代氨基甲酸盐（L3））的铂(IV)和钯(II)二硫代氨基甲酸盐配合物的三苯基膦加合物，并通过元素分析、电子、红外、¹H NMR和¹³C NMR光谱研究对其进行了表征。对这些配合物进行了热研究。已针对人腺癌细胞系筛选了体外抗肿瘤活性，结果表明即使在非常低的浓度下也有显著抑制作用。
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