Saygıdeğer Demir Burcu, Keleş Tuğba, Serindağ Osman
Department of Chemistry, Science, and Letters Faculty, Osmaniye Korkut Ata University, Fakıuşağı, 80000 Osmaniye, Turkey.
Department of Chemistry and Chemical Technology, University of Bayburt, 69000 Bayburt, Turkey.
Bioinorg Chem Appl. 2014;2014:717421. doi: 10.1155/2014/717421. Epub 2014 Dec 28.
Phosphine metal complexes have been recently evaluated in the field of cancer therapy. In this research, the cytotoxic effects of some metal phosphines {[PdCl2((CH2OH)2PCH2)2NCH3] (C1), [RuCl2(((CH2OH)2PCH2)2NCH3)2] (C2), [PtCl2((Ph2PCH2)2NCH3)(timin)2] (C3)} on K562 (human myelogenous leukemia cell line) and A549 (adenocarcinomic human alveolar basal epithelial cells) cells were investigated using the MTT test. C1 and C2 are water-soluble metal complexes, which may have some advantages in in vitro and in vivo studies. The effects of the above-mentioned metal complexes on thioredoxin reductase (TrxR) (EC: 1.8.1.9), glutathione peroxidase (GPx) (EC: 1.11.1.9), and catalase (Cat) (EC: 1.11.1.6) enzymes were also tested. The results of this research showed that all three metal complexes indicated dose-dependent cytotoxicity on A549 and K562 cell lines and that the complexes inhibited different percentages of the TrxR, GPx, and Cat enzymes of these tumor cells.
膦金属配合物最近在癌症治疗领域得到了评估。在本研究中，使用MTT试验研究了一些金属膦{[PdCl2((CH2OH)2PCH2)2NCH3] (C1)、[RuCl2(((CH2OH)2PCH2)2NCH3)2] (C2)、[PtCl2((Ph2PCH2)2NCH3)(timin)2] (C3)}对K562（人髓性白血病细胞系）和A549（人肺泡基底上皮腺癌细胞）细胞的细胞毒性作用。C1和C2是水溶性金属配合物，在体外和体内研究中可能具有一些优势。还测试了上述金属配合物对硫氧还蛋白还原酶（TrxR）（EC：1.8.1.9）、谷胱甘肽过氧化物酶（GPx）（EC：1.11.1.9）和过氧化氢酶（Cat）（EC：1.11.1.6）的影响。本研究结果表明，所有三种金属配合物对A549和K562细胞系均表现出剂量依赖性细胞毒性，并且这些配合物对这些肿瘤细胞的TrxR、GPx和Cat酶有不同程度的抑制作用。
