成人急性淋巴细胞白血病微小残留病的分子检测与早期复发相关。
Molecular detection of minimal residual disease is associated with early relapse in adult acute lymphoblastic leukemia.
作者信息
Specchia Giorgina, Liso Arcangelo, Pannunzio Alessandra, Albano Francesco, Mestice Anna, Pastore Domenico, Liso Vincenzo
出版信息
Haematologica. 2004 Oct;89(10):1271-3.
PMID:15477219
Abstract
Several studies in childhood acute lymphoblastic leukemia (ALL) have documented that molecular detection of minimal residual disease (MRD) based on screening for T-cell receptor and immunoglobulin gene rearrangements can identify patients at a high risk of relapse. In our experience, evaluation of MRD in adult ALL can help to identify high risk patients.
摘要
多项针对儿童急性淋巴细胞白血病（ALL）的研究表明，基于筛查T细胞受体和免疫球蛋白基因重排进行微小残留病（MRD）的分子检测能够识别出复发风险高的患者。根据我们的经验，对成人ALL患者进行MRD评估有助于识别高危患者。
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