激素替代疗法与心血管疾病：哪里出了问题，我们该何去何从？

Hormone replacement therapy and cardiovascular disease: what went wrong and where do we go from here?

作者信息

Dubey Raghvendra K, Imthurn Bruno, Zacharia Lefteris C, Jackson Edwin K

机构信息

Center for Clinical Pharmacology, University of Pittsburgh Medical Center, Pittsburgh, Pa, USA.

出版信息

Hypertension. 2004 Dec;44(6):789-95. doi: 10.1161/01.HYP.0000145988.95551.28. Epub 2004 Oct 11.

DOI:10.1161/01.HYP.0000145988.95551.28

PMID:15477384

Abstract

Observational studies in humans and experimental studies in animals and isolated cells supported the widely held belief that hormone replacement therapy protects the cardiovascular system from disease. To nearly everyone's astonishment, the Women's Health Initiative Study and the Heart and Estrogen/Progestin Replacement Study overturned the conclusion that hormone replacement therapy protects the cardiovascular system and, in fact, supported the opposite view that such therapy may actually increase the risk of cardiovascular disease. This review addresses 2 questions: what went wrong and where do we go from here?

摘要

针对人类的观察性研究以及针对动物和分离细胞的实验性研究，支持了一种广泛持有的观点，即激素替代疗法可保护心血管系统免受疾病侵害。几乎令所有人惊讶的是，妇女健康倡议研究以及心脏与雌激素/孕激素替代研究推翻了激素替代疗法可保护心血管系统这一结论，实际上支持了相反的观点，即这种疗法可能实际上会增加心血管疾病的风险。这篇综述探讨了两个问题：哪里出了问题以及我们从这里该何去何从？