小鼠IFN-α1转基因在单纯疱疹病毒1型眼部感染中诱导CXCL10和IL-6的后果。
Consequences of CXCL10 and IL-6 induction by the murine IFN-alpha1 transgene in ocular herpes simplex virus type 1 infection.
作者信息
Wickham Stephanie, Ash John, Lane Thomas E, Carr Daniel J J
机构信息
Department of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA.
出版信息
Immunol Res. 2004;30(2):191-200. doi: 10.1385/IR:30:2:191.
Abstract
Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of type I interferon transgenes has been found to antagonize viral replication and spread from the eye to the nervous system. Associated with the in situ transfection of the cornea is the upregulation of two inflammatory molecules, interleukin-6 and CXCL10. In this article, we will further examine the contribution these molecules may have in the host response to ocular infection with herpes simplex virus type 1.
摘要
单纯疱疹病毒1型感染小鼠眼睛会引发显著的炎症反应，最终导致动物死亡或建立“潜伏”感染，这取决于许多尚不明确的变量，包括先天和适应性免疫系统的组成部分。已发现应用I型干扰素转基因可拮抗病毒复制以及从眼睛向神经系统的传播。与角膜的原位转染相关的是两种炎症分子白细胞介素-6和CXCL10的上调。在本文中，我们将进一步研究这些分子在宿主对单纯疱疹病毒1型眼部感染的反应中可能发挥的作用。
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