暴露于屋尘螨过敏原的致敏恒河猴幼崽远端气道平滑肌肥大。
Smooth muscle hypertrophy in distal airways of sensitized infant rhesus monkeys exposed to house dust mite allergen.
作者信息
Tran M-U T, Weir A J, Fanucchi M V, Rodriguez A E, Pantle L M, Smiley-Jewell S M, Van Winkle L S, Evans M J, Miller L A, Schelegle E S, Gershwin L J, Hyde D M, Plopper C G
机构信息
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
出版信息
Clin Exp Allergy. 2004 Oct;34(10):1627-33. doi: 10.1111/j.1365-2222.2004.02057.x.
BACKGROUND
Airway smooth muscle hypertrophy is closely associated with the pathophysiology of hyper-reactive airways in allergic asthma.
OBJECTIVE
To determine whether repeated exposure to allergens during postnatal lung development promotes remodelling of airway smooth muscle.
METHODS
Infant, male rhesus monkeys (30-day-old) were sensitized to house dust mite allergen (HDMA) and then exposed to HDMA aerosol periodically over 5 months. Smooth muscle mass and bundle size and abundance in conducting airways were measured and compared with age-matched control (filtered air-exposed) monkeys.
RESULTS
Total smooth muscle mass and average bundle size were significantly greater in the conducting airways of monkeys exposed to HDMA. Smooth muscle bundle abundance was not affected by exposure to HDMA.
CONCLUSION
Repeated cycles of allergen exposure alter postnatal morphogenesis of smooth muscle, affecting both total mass and bundle size, in conducting airways of infant monkeys.
背景
气道平滑肌肥大与过敏性哮喘中气道高反应性的病理生理学密切相关。
目的
确定出生后肺部发育期间反复接触过敏原是否会促进气道平滑肌重塑。
方法
对30日龄雄性恒河猴幼崽进行屋尘螨过敏原（HDMA）致敏，然后在5个月内定期让其接触HDMA气雾剂。测量传导气道中的平滑肌质量、束大小和丰度，并与年龄匹配的对照（暴露于过滤空气）猴进行比较。
结果
暴露于HDMA的猴的传导气道中，平滑肌总质量和平均束大小显著更大。平滑肌束丰度不受HDMA暴露的影响。
结论
反复接触过敏原的周期会改变幼猴传导气道中平滑肌的出生后形态发生，影响总质量和束大小。
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