Hunt Carl E, Corwin Michael J, Baird Terry, Tinsley Larry R, Palmer Paula, Ramanathan Rangasamy, Crowell David H, Schafer Susan, Martin Richard J, Hufford David, Peucker Mark, Weese-Mayer Debra E, Silvestri Jean M, Neuman Michael R, Cantey-Kiser Jean
National Center on Sleep Disorders Research, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, Ste 6022, Bethesda, MD 20892-7993, USA.
J Pediatr. 2004 Oct;145(4):465-71. doi: 10.1016/j.jpeds.2004.05.045.
To determine if infants with cardiorespiratory events detected by home memory monitoring during early infancy have decreased neurodevelopmental performance.
Infants (n = 256) enrolled in the Collaborative Home Infant Monitoring Evaluation also completed the Bayley Scales of Infant Development II at 92 weeks' postconceptional age. Infants were classified as having 0, 1 to 4, or 5+ cardiorespiratory events. Events were defined as apnea >or=20 seconds or heart rate <60 to 80 bpm or <50 to 60 bpm, for >or=5 to 15 seconds, depending on age.
For term infants, having 0, 1 to 4, and 5+ cardiorespiratory events was associated with unadjusted mean Mental Developmental Index (MDI) values (+/-SD) of 103.6 (10.6), 104.2 (10.7), and 97.7 (10.9), respectively, and mean Psychomotor Developmental Index (PDI) values of 109.5 (16.6), 105.8 (16.5), and 100.2 (17.4). For preterm infants, having 0, 1 to 4, and 5+ cardiorespiratory events was associated with unadjusted mean MDI values of 100.4 (10.3), 96.8 (11.5), and 95.8 (10.6), respectively, and mean PDI values of 91.7 (19.2), 93.8 (15.5), and 94.4 (17.7). The adjusted difference in mean MDI scores with 5+ events compared with 0 events was 5.6 points lower in term infants ( P = .03) and 4.9 points lower in preterm infants ( P = .04).
Having 5+ conventional events is associated with lower adjusted mean differences in MDI in term and preterm infants.
确定在婴儿早期通过家庭记忆监测检测到有心肺事件的婴儿其神经发育表现是否降低。
参与“家庭婴儿监测协作评估”的婴儿（n = 256）在孕龄92周时还完成了贝利婴儿发育量表第二版测试。婴儿被分为发生0次、1至4次或5次以上心肺事件。事件定义为呼吸暂停≥20秒或心率<60至80次/分钟或<50至60次/分钟，持续≥5至15秒，具体取决于年龄。
对于足月儿，发生0次、1至4次和5次以上心肺事件时，未经调整的平均智力发育指数（MDI）值（±标准差）分别为103.6（10.6）、104.2（10.7）和97.7（10.9），平均心理运动发育指数（PDI）值分别为109.5（16.6）、105.8（16.5）和100.2（17.4）。对于早产儿，发生0次、1至4次和5次以上心肺事件时，未经调整的平均MDI值分别为100.4（10.3）、96.8（11.5）和95.8（10.6），平均PDI值分别为91.7（19.2）、93.8（15.5）和94.4（17.7）。与发生0次事件相比，发生5次以上事件的足月儿平均MDI评分经调整后的差异低5.6分（P = 0.03），早产儿低4.9分（P = 0.04）。
发生5次以上传统事件与足月儿和早产儿经调整后的平均MDI差异较低有关。
