腺病毒载体经肝动脉隔离灌注后中和抗体形成受损及转导效率高。
Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors.
作者信息
van Etten B, Eggermont A M M, Ambagtsheer G, van Tiel S T, ten Hagen T L M
机构信息
Erasmus University Medical Centre-Daniel den Hoed Cancer Centre, Department of Surgical Oncology, PO Box 5201, 3008 AE Rotterdam, The Netherlands.
出版信息
Br J Cancer. 2004 Oct 18;91(8):1610-3. doi: 10.1038/sj.bjc.6602151.
Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP. A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.
局部腺病毒基因转移可通过离体肝脏灌注（IHP）来进行。这种方法是递送腺病毒载体的一种非常有效且安全的方式。我们研究了离体肝脏灌注后的免疫反应。观察到中和抗体形成减少，这为在离体灌注环境下的基因治疗领域进一步研究提供了可能性。
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