浸润性淋巴细胞增多综合征中的肌炎：临床病理观察与治疗

Myositis in infiltrative lymphocytosis syndrome: clinicopathological observations and treatment.

作者信息

Attarian S, Mallecourt C, Donnet A, Pouget J, Pellisser J F

机构信息

Department of Neurology and Neuromuscular Diseases, CHU de La Timone, 264 rue Saint-Pierre, Marseilles cedex 13385, France.

出版信息

Neuromuscul Disord. 2004 Nov;14(11):740-3. doi: 10.1016/j.nmd.2004.05.018.

DOI:10.1016/j.nmd.2004.05.018

PMID:15482959

Abstract

Diffuse infiltrative lymphocytosis syndrome (DILS) is characterized by the presence of persistent circulating CD8 lymphocytosis and visceral CD8 lymphocytic infiltration, predominantly in the salivary glands and lungs in a subset of human immunodeficiency virus (HIV) patients. Myositis has been rarely documented in DILS. We report here the histopathological abnormalities and treatment response of an HIV patient with DILS associated myositis. Muscle biopsy revealed features of polymyositis but electron microscopy study showed intranuclear filamentous inclusions of 18 nm diameter, without intracytoplasmic inclusion. Treatment with intravenous immunoglobuline was useful.

摘要

弥漫性浸润性淋巴细胞增多综合征（DILS）的特征是存在持续循环的CD8淋巴细胞增多以及内脏CD8淋巴细胞浸润，主要见于一部分人类免疫缺陷病毒（HIV）患者的唾液腺和肺部。DILS合并肌炎的情况鲜有报道。我们在此报告一例患有DILS相关肌炎的HIV患者的组织病理学异常及治疗反应。肌肉活检显示为多发性肌炎特征，但电子显微镜研究显示有直径18nm的核内丝状包涵体，无胞质内包涵体。静脉注射免疫球蛋白治疗有效。