Tamayo M, Fernández de Gatta M M, García M J, Domínguez-Gil A
Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Spain.
J Clin Pharm Ther. 1992 Feb;17(1):55-9. doi: 10.1111/j.1365-2710.1992.tb01266.x.
Three methods for estimating maintenance dosage requirements of imipramine were compared retrospectively in 146 enuretic patients. The dosing methods evaluated included individual (serum levels data) and/or population (average pharmacokinetic parameter) information. The use of imipramine and desipramine serum concentrations, as opposed to average population parameters only, improved forecast precision and accuracy for dosage individualization. The clinical acceptability of this was achieved through knowledge of a single serum concentration. No significant differences were seen between non-linear regression and the Bayesian method, this is in agreement with the high contribution of the patient's data to the Bayesian fitting (FF = 0.8). When one or two serum level data were available, a better performance was obtained by estimating pharmacokinetic parameters than level:dose ratios.
对146例遗尿症患者回顾性比较了三种估算丙咪嗪维持剂量需求的方法。评估的给药方法包括个体（血清水平数据）和/或群体（平均药代动力学参数）信息。与仅使用群体平均参数相比，使用丙咪嗪和去甲丙咪嗪血清浓度可提高剂量个体化的预测精度和准确性。通过了解单一血清浓度即可实现这一点的临床可接受性。非线性回归和贝叶斯方法之间未观察到显著差异，这与患者数据对贝叶斯拟合的高贡献（FF = 0.8）一致。当有一两个血清水平数据时，通过估算药代动力学参数比估算水平：剂量比能获得更好的效果。
