Einsiedel Lloyd, Gordon David L, Dyer John R
Department of Microbiology and Infectious Diseases, Flinders Medical Centre, Bedford Park, South Australia, Australia.
Clin Infect Dis. 2004 Oct 15;39(8):e78-82. doi: 10.1086/424746. Epub 2004 Sep 27.
A human immunodeficiency virus (HIV)-seronegative woman was admitted to the hospital with postpartum onset Cryptococcus neoformans var. gattii meningitis and markedly increased intracranial pressure. A poor initial response to antifungal therapy was followed, 2 months after hospital admission, by severe acute meningeal and cerebral inflammation and clearance of yeast cells from cerebrospinal fluid. This first reported case of paradoxical inflammatory reaction to C. neoformans illustrates important aspects of the host-pathogen interaction and highlights possible effects of immunomodulatory therapies.
一名人类免疫缺陷病毒（HIV）血清学阴性的女性因产后发生新型隐球菌格特变种脑膜炎及颅内压显著升高入院。抗真菌治疗初期反应不佳，入院2个月后，出现严重的急性脑膜和脑部炎症，脑脊液中酵母细胞清除。这例首次报道的新型隐球菌矛盾性炎症反应病例说明了宿主-病原体相互作用的重要方面，并突出了免疫调节疗法的可能效果。
