Chou Thomas C, Rotman Stephen R, Saper Clifford B
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Neurosci Lett. 2004 Nov 11;370(2-3):123-6. doi: 10.1016/j.neulet.2004.08.070.
The lateral hypothalamic area (LHA) contains a large population of neurons that express the enzyme acetylcholinesterase (AChE), but are not themselves cholinergic. Some of these neurons have been shown to contain melanin-concentrating hormone (MCH), a neuropeptide implicated in regulating feeding, but the identities of the remaining neurons are unknown. We now report that nearly all AChE-immunoreactive neurons in the LHA express immunoreactivity for either MCH or for orexin, a peptide implicated in regulating wakefulness. Furthermore, most orexin neurons and MCH neurons appear to contain AChE. AChE immunoreactivity appears to be a key feature of nearly all of the diffusely-projecting cortical systems.
外侧下丘脑区（LHA）包含大量表达乙酰胆碱酯酶（AChE）的神经元，但这些神经元本身并非胆碱能神经元。其中一些神经元已被证明含有黑色素浓缩激素（MCH），这是一种与调节进食有关的神经肽，但其余神经元的身份尚不清楚。我们现在报告，LHA中几乎所有AChE免疫反应性神经元都对MCH或食欲素（一种与调节觉醒有关的肽）表达免疫反应性。此外，大多数食欲素神经元和MCH神经元似乎都含有AChE。AChE免疫反应性似乎是几乎所有弥散投射皮质系统的一个关键特征。
