Da Silva Renata A, de Oliveira Silvana Tomazoni, Hackl Luciane P N, Spilere Caroline Inacio, Faria Moacir Serralvo, Marino-Neto José, Paschoalini Marta A
Department of Physiological Sciences, CCB, Federal University of Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
Brain Res. 2004 Nov 12;1026(2):275-83. doi: 10.1016/j.brainres.2004.08.031.
The effects of intracerebroventricular injections of 8-OH-DPAT (a 5-HT1A agonist; 3, 15 or 30 nmol) or GR46611 (a 5-HT1B/1D agonist; 3, 15 or 30 nmol) on feeding, drinking, preening and sleep-like behaviors were investigated in free-feeding (FF) pigeons. The effects of these 5-HT agonists on blood glucose and free fatty acids levels were also examined. Injections of 8-OH-DPAT evoked intense lipolytic and dipsogenic effects, but failed to affect feeding, non-ingestive behaviors and glycemic levels. On the other hand, GR46611 evoked significant increases in food intake (at the higher dose), as well as lipolytic and hyperglycemic effects, but left drinking and other non-ingestive behaviors unchanged. These effects are opposed to those found in rodents, and may be associated with the diverse, species-specific nature and distribution of these receptors, underscoring the need to examine the functional aspects of the 5-HT1 receptor family in a more extensive range of non-rodent species.
研究了向自由进食（FF）鸽子脑室内注射8-OH-DPAT（一种5-HT1A激动剂；3、15或30纳摩尔）或GR46611（一种5-HT1B/1D激动剂；3、15或30纳摩尔）对进食、饮水、理毛和睡眠样行为的影响。还检测了这些5-羟色胺激动剂对血糖和游离脂肪酸水平的影响。注射8-OH-DPAT引起强烈的脂肪分解和致渴作用，但未影响进食、非摄食行为和血糖水平。另一方面，GR46611引起食物摄入量显著增加（在较高剂量时），以及脂肪分解和高血糖作用，但饮水和其他非摄食行为未改变。这些作用与在啮齿动物中发现的作用相反，可能与这些受体的多样性、物种特异性性质和分布有关，强调需要在更广泛的非啮齿动物物种范围内研究5-HT1受体家族的功能方面。
