van der Ven Karlijn, Van Dongen Walter, Maes Bert U W, Esmans Eddy L, Blust Ronny, De Coen Wim M
Department of Biology, Laboratory of Ecophysiology, Biochemistry and Toxicology, University of Antwerp (RUCA), Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
Chemosphere. 2004 Nov;57(8):967-73. doi: 10.1016/j.chemosphere.2004.08.062.
In recent years growing attention has been paid toward the discharge, presence and potential adverse effects of pharmaceuticals in the environment. Using different existing analytical methods several studies have already identified a variety of drugs in waste-, surface- and drinking water. The monitoring of surface waters for drugs is of great importance because drugs are designed to be biological very active substances. A capillary LC/ES-MS-MS method has been developed that enables the sensitive and specific detection of diazepam in water samples up to 0.1 ng/ml (LOD). It requires neither multiple extraction steps, nor the use of large volumes of organic solvent. Applying this assay we have detected diazepam in 'in/effluent samples' collected in Belgium and demonstrated the applicability for water analysis without off-line pre-concentration of the analyte.
近年来，人们越来越关注药物在环境中的排放、存在及其潜在的不利影响。通过使用不同的现有分析方法，多项研究已经在废水、地表水和饮用水中鉴定出了多种药物。对地表水进行药物监测非常重要，因为药物被设计为具有很强生物活性的物质。已开发出一种毛细管液相色谱/电喷雾串联质谱法，该方法能够灵敏且特异检测水样中低至0.1纳克/毫升（检测限）的地西泮。它既不需要多个萃取步骤，也无需使用大量有机溶剂。应用该分析方法，我们在比利时采集的“进/出水样”中检测到了地西泮，并证明了该方法在不对分析物进行离线预浓缩的情况下用于水分析的适用性。
