罪名成立：B-RAF是一种人类致癌基因。

Guilty as charged: B-RAF is a human oncogene.

作者信息

Garnett Mathew J, Marais Richard

机构信息

Signal Transduction Team, Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom.

出版信息

Cancer Cell. 2004 Oct;6(4):313-9. doi: 10.1016/j.ccr.2004.09.022.

DOI:10.1016/j.ccr.2004.09.022

PMID:15488754

Abstract

RAF proteins are components of a conserved signaling pathway that regulates cellular responses to extracellular signals. Despite over 20 years of research into the regulation and function of the RAF proteins, it was only realized recently that the B-RAF isoform is mutated at a high frequency in human cancer. Here we review the rapid progress made in our understanding of B-RAF as an oncogene and of its role in cancer.

摘要

RAF蛋白是一种保守信号通路的组成部分，该信号通路调节细胞对细胞外信号的反应。尽管对RAF蛋白的调节和功能进行了20多年的研究，但直到最近才意识到B-RAF亚型在人类癌症中高频突变。在此，我们综述了在理解B-RAF作为一种癌基因及其在癌症中的作用方面所取得的快速进展。