Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea.
Int J Mol Sci. 2024 Nov 18;25(22):12387. doi: 10.3390/ijms252212387.
Cancer is a multifaceted disease influenced by various mechanisms, including the generation of reactive oxygen species (ROS), which have a paradoxical role in both promoting cancer progression and serving as targets for therapeutic interventions. At low concentrations, ROS serve as signaling agents that enhance cancer cell proliferation, migration, and resistance to drugs. However, at elevated levels, ROS induce oxidative stress, causing damage to biomolecules and leading to cell death. Cancer cells have developed mechanisms to manage ROS levels, including activating pathways such as NRF2, NF-κB, and PI3K/Akt. This review explores the relationship between ROS and cancer, focusing on cell death mechanisms like apoptosis, ferroptosis, and autophagy, highlighting the potential therapeutic strategies that exploit ROS to target cancer cells.
癌症是一种多方面的疾病，受到多种机制的影响，包括活性氧（ROS）的产生，ROS 在促进癌症进展和作为治疗干预的靶点方面具有矛盾的作用。在低浓度下，ROS 作为信号分子，增强癌细胞的增殖、迁移和对药物的抵抗力。然而，在高水平下，ROS 会引起氧化应激，导致生物分子受损，并导致细胞死亡。癌细胞已经发展出管理 ROS 水平的机制，包括激活 NRF2、NF-κB 和 PI3K/Akt 等途径。本综述探讨了 ROS 与癌症之间的关系，重点介绍了细胞死亡机制，如细胞凋亡、铁死亡和自噬，并强调了利用 ROS 靶向癌细胞的潜在治疗策略。
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