Nacher Juan, Gomez-Climent Maria Angeles, McEwen Bruce
Neurobiology, Cell Biology Department, Universitat de València, Dr. Moliner, 50, Burjassot 46100, Spain.
Neurosci Lett. 2004 Nov 3;370(1):40-4. doi: 10.1016/j.neulet.2004.07.062.
The expression of the polysialylated neural cell adhesion molecule (PSA-NCAM) is increased in the hippocampus after chronic restraint stress (CRS) and may play a permissive role in structural changes that include dendrite reorganization in dentate gyrus (DG) and CA3 pyramidal neurons and suppression of neurogenesis in DG. We report that chronic oral corticosterone (CORT) administration decreases the number of PSA-NCAM immunoreactive granule neurons in the adult rat dentate gyrus, and the available evidence suggests that this is an indirect effect of CORT, possibly involving excitatory amino acids, that may not be directly related to neurogenesis. Because CORT treatment reduces but does not eliminate PSA-NCAM expression, the present results do not exclude a permissive role for PSA-NCAM in CORT or CRS-induced structural plasticity in hippocampus.
慢性束缚应激（CRS）后，海马中多唾液酸化神经细胞黏附分子（PSA-NCAM）的表达增加，并且可能在结构变化中发挥允许作用，这些结构变化包括齿状回（DG）和CA3锥体神经元的树突重组以及DG中神经发生的抑制。我们报告，成年大鼠齿状回中慢性口服皮质酮（CORT）会减少PSA-NCAM免疫反应性颗粒神经元的数量，现有证据表明这是CORT的间接作用，可能涉及兴奋性氨基酸，这可能与神经发生没有直接关系。由于CORT治疗会降低但不会消除PSA-NCAM的表达，因此目前的结果不排除PSA-NCAM在CORT或CRS诱导的海马结构可塑性中发挥允许作用。
