齿叶林氏草中的环戊烷类氰醇苷和酰胺

Cyclopentanoid cyanohydrin glucosides and amides of Lindackeria dentata.

作者信息

Jaroszewski Jerzy W, Ekpe Patrick, Witt Matthias

机构信息

Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark.

出版信息

Planta Med. 2004 Oct;70(10):1001-3. doi: 10.1055/s-2004-832628.

DOI:10.1055/s-2004-832628

PMID:15490330

Abstract

A mixture of cyanogenic glucosides epivolkenin and taraktophyllin, 1,4-dihydroxy-2-cyclopentenecarboxamide, and uridine were isolated from leaves of Lindackeria dentata (Flacourtiaceae). Another cyclopentanoid amide, (1 R,4 S,5 R)-1,4,5-trihydroxy-2-cyclopentenecarboxamide, was synthesized in two steps from gynocardin, and shown to have the same relative configuration as a partially identified amide previously isolated from L. dentata bark.

摘要

从齿叶林氏木（大风子科）的叶子中分离出了含氰糖苷表伏肯宁和塔拉托菲林、1,4 - 二羟基 - 2 - 环戊烯甲酰胺以及尿苷的混合物。另一种环戊烷类酰胺，(1R,4S,5R)-1,4,5 - 三羟基 - 2 - 环戊烯甲酰胺，由副大风子酸经两步合成，并显示其相对构型与先前从齿叶林氏木树皮中分离出的一种部分鉴定的酰胺相同。