Van Duser B L, Raven P B
Department of Physiology, Texas College of Osteopathic Medicine, Fort Worth 76107.
Med Sci Sports Exerc. 1992 Mar;24(3):389-95.
The purpose of this investigation was to determine the effects of oral smokeless tobacco (OST) usage on oxygen uptake (VO2), cardiac output (Qc), stroke volume (SV), heart rate (HR), and plasma lactate concentration (Lc) during rest and exercise. Fifteen asymptomatic subjects were recruited from 18 to 33-yr-old male users of OST. Comparisons of the responses of VO2, Qc, SV, HR, and Lc were made between 2.5-g OST and placebo experimental conditions during rest and at 60% and 85% maximal VO2 treadmill exercise. Plasma nicotine concentrations (Nc) were determined by radioimmunoassay. There were significant increases in HR and Lc and a decrease in SV during rest and at 60% and 85% maximal exercise (P less than 0.05). Furthermore, there were no significant differences in maximal HR, Lc, and VO2 (P greater than 0.05). In conclusion, these data indicate that the increased Nc incurred by OST usage increases anaerobic energy production and produces an increased tachycardiac response to a given relative submaximal workload.
本研究的目的是确定使用口服无烟烟草（OST）对静息和运动期间的摄氧量（VO2）、心输出量（Qc）、每搏输出量（SV）、心率（HR）和血浆乳酸浓度（Lc）的影响。从18至33岁的男性OST使用者中招募了15名无症状受试者。在静息状态以及60%和85%最大摄氧量的跑步机运动状态下，比较了2.5克OST与安慰剂实验条件下VO2、Qc、SV、HR和Lc的反应。通过放射免疫测定法测定血浆尼古丁浓度（Nc）。静息状态以及60%和85%最大运动状态下，HR和Lc显著增加，SV降低（P<0.05）。此外，最大HR、Lc和VO2无显著差异（P>0.05）。总之，这些数据表明，使用OST导致的Nc增加会增加无氧能量产生，并对给定的相对次最大工作量产生增强的心动过速反应。
