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[斯氏假单胞菌引起的脑膜炎:一例报告]

[Meningitis due to Pseudomonas stutzeri: a case report].

作者信息

Taşdelen Fişgin Nuriye, Acuner Ibrahim Cağatay, Coban Ahmet Yilmaz, Fişgin Tunç, Birinci Asuman, Durupinar Belma

机构信息

Ondokuz Mayis Universitesi Tip Fakültesi, infeksiyon Hastaliklari ve Klinik Mikrobiyoloji Anabilim Dali, Samsun.

出版信息

Mikrobiyol Bul. 2004 Jul;38(3):261-4.

Abstract

Pseudomonas stutzeri is a saprophytic microorganism that rarely causes severe infections. In this report, a 28 days old male patient with meningomyelocele at birth was presented. The patient was admitted to the hospital with fever, and diagnosed as meningitis on the basis of physical examination and leukocytosis (blood: 16.380/mm3, cerebrospinal fluid (CSF): 130/mm3; 90% PMNL). Following diagnosis ceftriaxone therapy was started led to improvement in clinical and laboratory findings. However on the 20th day, the clinical signs and symptoms became worse, and the patient was diagnosed to develop a second meningitis attack by laboratory examination of CSF. P. stutzeri was isolated from the CSF culture, and the isolate was found to be resistant to ceftriaxone. Upon this result the therapy has changed to meropenem. On the 5th day of the therapy, the patient has slightly improved and he was discharged due to the wishes of his parents, however he died two days after discharge. This first case of P. stutzeri meningitis in neonates was presented to withdraw attention to this clinical entity.

摘要

斯氏假单胞菌是一种腐生微生物,很少引起严重感染。在本报告中,介绍了一名出生时患有脊髓脊膜膨出的28天大男性患者。该患者因发热入院,根据体格检查和白细胞增多症(血液:16380/mm³,脑脊液(CSF):130/mm³;90%中性粒细胞)被诊断为脑膜炎。诊断后开始头孢曲松治疗,临床和实验室检查结果有所改善。然而,在第20天,临床症状和体征恶化,通过脑脊液实验室检查诊断患者发生了第二次脑膜炎发作。从脑脊液培养物中分离出斯氏假单胞菌,发现分离株对头孢曲松耐药。基于此结果,治疗改为美罗培南。在治疗的第5天,患者稍有好转,因父母的意愿出院,但出院两天后死亡。本文报告了首例新生儿斯氏假单胞菌脑膜炎病例,以引起对这一临床实体的关注。

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