Hayaishi O, Urade Y, Eguchi N, Huang Z L
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 5650874, Japan.
Arch Ital Biol. 2004 Jul;142(4):533-9.
(1) Prostaglandin D2 is essential for the maintenance of the sleep state. (2) The adenosine and A2A receptor system is a link between the humoral and neural mechanisms of sleep-wake regulation. (3) Prostaglandin D2 plays a crucial role in the homeostatic regulation of NREM sleep. Finally, it may not be too far-fetched to say that prostaglandin D2 was most likely the endogenous sleep substance described by Piéron and Ishimori about 100 years ago, and possibly the sleep-inducing factor reported by Professor Jouvet and coworkers some twenty years ago.
(1) 前列腺素D2对维持睡眠状态至关重要。(2) 腺苷和A2A受体系统是睡眠-觉醒调节的体液机制与神经机制之间的联系。(3) 前列腺素D2在非快速眼动睡眠的稳态调节中起关键作用。最后，可以说前列腺素D2很可能就是大约100年前皮埃隆和石森所描述的内源性睡眠物质，也可能是约20年前朱维特教授及其同事报道的促眠因子，这种说法并非牵强附会。
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