腺苷作用是否为非快速动眼睡眠、蛰伏和其他低代谢状态的共同基础？
Is Adenosine Action Common Ground for NREM Sleep, Torpor, and Other Hypometabolic States?
机构信息
Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna , Bologna , Italy.
National Institute of Nuclear Physics (INFN), Section of Bologna, Bologna , Italy.
出版信息
Physiology (Bethesda). 2018 May 1;33(3):182-196. doi: 10.1152/physiol.00007.2018.
Abstract
This review compares two states that lower energy expenditure: non-rapid eye movement (NREM) sleep and torpor. Knowledge on mechanisms common to these states, and particularly on the role of adenosine in NREM sleep, may ultimately open the possibility of inducing a synthetic torpor-like state in humans for medical applications and long-term space travel. To achieve this goal, it will be important, in perspective, to extend the study to other hypometabolic states, which, unlike torpor, can also be experienced by humans.
摘要
这篇综述比较了两种降低能量消耗的状态
非快速眼动（NREM）睡眠和蛰伏。了解这些状态共有的机制，特别是腺苷在 NREM 睡眠中的作用，最终可能为人类医学应用和长期太空旅行诱导一种类似蛰伏的合成状态开辟可能性。展望未来，为了实现这一目标，将研究扩展到其他代谢率降低的状态将很重要，这些状态与蛰伏不同，人类也可以经历这些状态。
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