后期促进复合物（APC）：其各部分的总和？

The anaphase-promoting complex (APC): the sum of its parts?

作者信息

Passmore L A

机构信息

Section of Structural Biology, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

出版信息

Biochem Soc Trans. 2004 Nov;32(Pt 5):724-7. doi: 10.1042/BST0320724.

DOI:10.1042/BST0320724

PMID:15493998

Abstract

The APC (anaphase-promoting complex) is a multisubunit E3 ubiquitin ligase that targets cell-cycle-related proteins for degradation by the 26 S proteasome. The APC contains at least 13 subunits and is regulated by the binding of co-activator proteins and by phosphorylation. It is not known why the APC contains 13 subunits when many other ubiquitin ligases are small single-subunit enzymes. In the present study, the structures and functions of individual APC subunits are discussed. By dissecting the roles of its parts, we hope to gain insight into the mechanism of the intact APC.

摘要

后期促进复合物（APC）是一种多亚基E3泛素连接酶，它靶向与细胞周期相关的蛋白质，使其被26S蛋白酶体降解。APC至少包含13个亚基，并通过共激活蛋白的结合和磷酸化进行调节。目前尚不清楚为什么当许多其他泛素连接酶是小的单亚基酶时，APC却包含13个亚基。在本研究中，将讨论各个APC亚基的结构和功能。通过剖析其各个部分的作用，我们希望深入了解完整APC的机制。