1989 - 2002年HIV感染患者中艾滋病界定性和非艾滋病界定性恶性肿瘤的发病趋势

Trends in AIDS-defining and non-AIDS-defining malignancies among HIV-infected patients: 1989-2002.

作者信息

Bedimo Roger, Chen Ray Y, Accortt Neil A, Raper James L, Linn Carol, Allison Jeroan J, Dubay John, Saag Michael S, Hoesley Craig J

机构信息

University of Alabama at Birmingham, USA.

出版信息

Clin Infect Dis. 2004 Nov 1;39(9):1380-4. doi: 10.1086/424883. Epub 2004 Oct 11.

DOI:10.1086/424883

PMID:15494916

Abstract

In a comparison of rates of acquired immunodeficiency syndrome (AIDS)-defining malignancies (ADMs) for 1989-1996 versus 1997-2002, we found a decrease in ADMs (rate ratio, 0.31; P<.0001) and a significant increase in non-AIDS-defining malignancies (non-ADMs; rate ratio, 10.87; P<.0002). The mean CD4 cell count was lower among patients with ADMs than among those with non-ADMs. A longer duration of survival during highly active antiretroviral therapy might explain the increasing incidence of non-ADMs.

摘要

在比较1989 - 1996年与1997 - 2002年获得性免疫缺陷综合征（AIDS）定义的恶性肿瘤（ADM）发生率时，我们发现ADM发生率下降（率比为0.31；P <.0001），而非AIDS定义的恶性肿瘤（非ADM）显著增加（率比为10.87；P <.0002）。ADM患者的平均CD4细胞计数低于非ADM患者。高效抗逆转录病毒治疗期间较长的生存时间可能解释了非ADM发病率的增加。