Lejeune Jeffrey T, Abedon Stephen T, Takemura Kaori, Christie Nicholas P, Sreevatsan Srinand
Ohio State University, Wooster, Ohio 44691, USA.
Emerg Infect Dis. 2004 Aug;10(8):1482-5. doi: 10.3201/eid1008.030784.
The antiterminator Q gene of bacteriophage 933W (Q933) was identified upstream of the stx2 gene in 90% of human disease-origin Escherichia coli O157:H7 isolates and in 44.5% of bovine isolates. Shiga toxin production was higher in Q933-positive isolates than Q933-negative isolates. This genetic marker may provide a useful molecular tool for epidemiologic studies.
噬菌体933W（Q933）的抗终止子Q基因在90%的人类疾病源大肠杆菌O157:H7分离株以及44.5%的牛分离株中，位于stx2基因上游被鉴定出来。Q933阳性分离株的志贺毒素产量高于Q933阴性分离株。这一遗传标记可能为流行病学研究提供一种有用的分子工具。
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