C-脂肪族高烯丙基胺及具有重要生物学意义的环己烯基胺类似物的不对称合成。
Asymmetric synthesis of C-aliphatic homoallylic amines and biologically important cyclohexenylamine analogues.
作者信息
Ken Lee Chi-Lik, Ling Hui Yvonne, Loh Teck-Peng
机构信息
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
出版信息
J Org Chem. 2004 Oct 29;69(22):7787-9. doi: 10.1021/jo048903o.
PMID:15498019
Abstract
An efficient method for the asymmetric synthesis of C-aliphatic homoallylic amines with up to 94% yield and 80% de is reported. Ring-closing metathesis of several chiral homoallylic amines using the second-generation Grubbs catalyst provided easy access to a wide variety of cyclohexenylamines.
摘要
报道了一种高效的不对称合成C-脂肪族高烯丙基胺的方法，产率高达94%，对映体过量值为80%。使用第二代格拉布催化剂对几种手性高烯丙基胺进行闭环复分解反应，可方便地制备多种环己烯基胺。
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