Dolman Sarah J, Schrock Richard R, Hoveyda Amir H
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Org Lett. 2003 Dec 11;5(25):4899-902. doi: 10.1021/ol036026n.
Carbocyclic amines are synthesized efficiently in up to 93% ee by asymmetric ring-closing metathesis (ARCM) with 2-5 mol % chiral Mo complexes. An example is provided where the catalyst is prepared in situ (catalyst isolation not needed) to afford secondary amines that cannot be prepared by alternative methods. [reaction: see text]
通过使用2 - 5摩尔%的手性钼配合物进行不对称闭环复分解反应（ARCM），可高效合成碳环胺，对映体过量率高达93%。文中给出了一个示例，即原位制备催化剂（无需分离催化剂）以得到无法通过其他方法制备的仲胺。[反应：见正文]
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