A fifty-nine year old man is reported herein with a hyperkeratotic papular eruption that clinically and histologically was compatible with Kyrle's disease (hyperkeratosis follicularis et parafollicularis in cutem penetrans). Treatment with tretinoin (topical vitamine A acid) resulted in a severe inflammatory reactions in the lesions which persisted for four monthes and did not prevent a mild recurrence of the disease. The clinical and histologic differential diagnosis is reviewed perforating folliculitis, reactive perforating collagenosis, and elastosis perforans serpiginosa. The close similarity between Kyrle's disease and perforating folliculitis often makes absolute diagnosis very difficult.
本文报道了一名59岁男性，其患有角化过度性丘疹性皮疹，临床和组织学表现均符合凯尔氏病（穿通性毛囊及毛囊旁角化过度症）。使用维甲酸（外用维生素A酸）治疗导致皮损出现严重炎症反应，持续了四个月，且未能阻止疾病轻度复发。对穿通性毛囊炎、反应性穿通性胶原病和匐行性穿通性弹力纤维病进行了临床和组织学鉴别诊断。凯尔氏病与穿通性毛囊炎之间的密切相似性常常使得明确诊断非常困难。
