[人乳头瘤病毒（HPV）感染及其与口腔和口咽鳞状细胞癌的关系]

[Human papillomavirus (HPV) infection and its relation with squamous cell carcinoma of the mouth and oropharynx].

作者信息

Tinoco José Alberto, Silva Alessandra Furtado da, Oliveira Carlos Alberto Basílio de, Rapoport Abrão, Fava Antonio Sérgio, Souza Ricardo Pires de

机构信息

Departamento de Cirurgia de Cabeça, Pescoço, e Otorrinolaringologia, Hospital Heliópolis, São Paulo, SP.

出版信息

Rev Assoc Med Bras (1992). 2004 Jul-Sep;50(3):252-6. doi: 10.1590/s0104-42302004000300029. Epub 2004 Oct 21.

DOI:10.1590/s0104-42302004000300029

PMID:15499474

Abstract

OBJECTIVE

To establish a connection between infection by the human papilloma virus (HPV) and development of malignant (squamous cell carcinoma) and benign lesions (epithelial hyperplasia papillomatosis and papilloma) of the oral cavity and oropharynx.

METHOD

A retrospective study of 66 blades and paraffin blocks with biopsy tissue fixed with formalin. This material, collected in 2002, refers to a group of 44 men (66.7%) and 22 women (33.3%) with ages ranging from 11 to 100 years, with confirmed diagnoses of squamous cell carcinoma in 38 cases, of epithelial hyperplasia papillomatosis in 20 cases and of papillomas in 8 cases. This material was analyzed by immunohistochemistry and the presence of viral DNA in the biopsy samples was determined.

RESULTS

Presence of the viral DNA (HPV) in 16 of the 38 cases of carcinoma (42.5%), 19 in 20 cases of hyperplasia (95%) and 8 in 8 cases of papilloma (100%) was detected.

CONCLUSION

The samples in this study show the predominant incidence of the HPV in the epithelial hyperplasia papillomatosis and papilloma in relation to squamous cell carcinoma. This last lesion, on the other hand, did not show statistical correlation to the HPV.

摘要

目的

建立人乳头瘤病毒（HPV）感染与口腔及口咽恶性病变（鳞状细胞癌）和良性病变（上皮增生乳头瘤病和乳头状瘤）之间的联系。

方法

对66个用福尔马林固定的活检组织刀片和石蜡块进行回顾性研究。该材料于2002年收集，涉及一组年龄在11至100岁之间的44名男性（66.7%）和22名女性（33.3%），其中38例确诊为鳞状细胞癌，20例为上皮增生乳头瘤病，8例为乳头状瘤。对该材料进行免疫组织化学分析，并测定活检样本中病毒DNA的存在情况。