通过 PCR 技术检测健康人群正常口腔黏膜中人乳头瘤病毒的频率。
The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR.
机构信息
Universidade Federal do Rio de Janeiro, Brazil.
出版信息
Braz J Otorhinolaryngol. 2010 Jan-Feb;76(1):78-84. doi: 10.1590/S1808-86942010000100013.
Abstract
UNLABELLED
The human papillomavirus (HPV) is a DNA virus, which belongs to papillomaviridae family, being of low and high risk, which infect the skin and mucous membranes and can induce benign and malign tumor formation. In the oral mucosa they have been associated with oral papilloma, focal epithelial hyperplasia, leucoplakia and oral neoplasia.
AIM
to study the frequency of HPV finding in oral mucosa of normal people.
MATERIALS AND METHODS
Prospective study, cross-sectional cohort. One hundred volunteers, young adults, healthy, aged between 20 and 31 years, university students with no history, no complains, without oral or oropharyngeal lesions. They were submitted to a questionnaire with questions regarding HPV infection epidemiology. The samples were harvested by brushing and analyzed by PCR.
RESULTS
The results were negative for HPV in all samples.
CONCLUSION
It seems we had high social and economical class individuals, with nutrition rich in carotenoyds and vitamin C, low smoking and alcohol consumption and heterosexual habits with predominant monogamy and regular use of condoms.
摘要
目的
研究人乳头瘤病毒（HPV）在正常人口腔黏膜中的发现频率。
材料和方法
前瞻性研究，横断面队列。100 名志愿者，年轻人，健康，年龄在 20 至 31 岁之间，为大学生，无病史，无主诉，无口腔或口咽病变。他们接受了一份关于 HPV 感染流行病学的问卷。通过刷拭采集样本，并通过 PCR 进行分析。
结果
所有样本的 HPV 检测结果均为阴性。
结论
我们的研究对象似乎来自社会经济地位较高的人群，他们的饮食富含类胡萝卜素和维生素 C，吸烟和饮酒较少，性习惯为异性恋，以一夫一妻制为主，且经常使用避孕套。
相似文献
1
The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR.通过 PCR 技术检测健康人群正常口腔黏膜中人乳头瘤病毒的频率。
Braz J Otorhinolaryngol. 2010 Jan-Feb;76(1):78-84. doi: 10.1590/S1808-86942010000100013.
2
Brushing of oral mucosa for diagnosis of HPV infection in patients with potentially malignant and malignant oral lesions.对潜在恶性和恶性口腔病变患者的口腔黏膜进行刷检以诊断HPV感染。
Mol Diagn Ther. 2006;10(1):49-55. doi: 10.1007/BF03256442.
3
Epidemiological study of HPV in oral mucosa through PCR.口腔黏膜 HPV 的 PCR 流行病学研究。
Braz J Otorhinolaryngol. 2012 Jul-Aug;78(4):66-70. doi: 10.1590/S1808-86942012000400013.
4
Association between oral DNA-HPV and genital DNA-HPV.口腔DNA人乳头瘤病毒与生殖器DNA人乳头瘤病毒之间的关联。
J Oral Pathol Med. 2014 Apr;43(4):289-92. doi: 10.1111/jop.12141. Epub 2013 Dec 10.
5
Low prevalence of high risk genotypes of human papilloma virus in normal oral mucosa, oral leukoplakia and verrucous carcinoma.正常口腔黏膜、口腔白斑病和疣状癌中人乳头瘤病毒高危基因型的低流行率。
Acta Odontol Scand. 2011 Nov;69(6):406-9. doi: 10.3109/00016357.2011.572560. Epub 2011 Apr 5.
6
7
Human papilloma virus in oral mucosa and its association with periodontal status of gynecologically infected women.口腔黏膜中的人乳头瘤病毒及其与妇科感染女性牙周状况的关联。
Acta Odontol Latinoam. 2014;27(2):82-8. doi: 10.1590/S1852-48342014000200007.
8
"High risk" HPV types are frequently detected in potentially malignant and malignant oral lesions, but not in normal oral mucosa.“高危”型人乳头瘤病毒（HPV）常在潜在恶性和恶性口腔病变中被检测到，但在正常口腔黏膜中未被检测到。
Mod Pathol. 2000 Jun;13(6):644-53. doi: 10.1038/modpathol.3880113.
9
The prevalence and distribution of human papillomavirus genotypes in oral epithelial hyperplasia: proposal of a concept.口腔上皮增生中人类乳头瘤病毒基因型的流行情况与分布：一个概念的提出
J Oral Pathol Med. 2009 Feb;38(2):181-7. doi: 10.1111/j.1600-0714.2008.00723.x. Epub 2008 Dec 26.
10
Low prevalence of human papillomavirus infection in the healthy oral mucosa of a Northern Italian population.意大利北部人群健康口腔黏膜中人乳头瘤病毒感染率较低。
J Oral Pathol Med. 2012 Jan;41(1):16-20. doi: 10.1111/j.1600-0714.2011.01062.x. Epub 2011 Jul 18.
引用本文的文献
1
The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study.人乳头瘤病毒阳性与阴性口腔黏膜病变随访的必要性：一项回顾性研究
J Clin Med. 2023 Dec 21;13(1):58. doi: 10.3390/jcm13010058.
2
Prevalence of Human Papillomavirus (HPV)-16 in Different Dental Infections in the Lebanese Population.黎巴嫩人群不同牙齿感染中人类乳头瘤病毒（HPV）-16的流行情况。
Cureus. 2023 May 9;15(5):e38809. doi: 10.7759/cureus.38809. eCollection 2023 May.
3
Prevalence of Human Papillomavirus (HPV) in the Oral Cavity of a Healthy Population in South-Eastern Poland.波兰东南部健康人群口腔人乳头瘤病毒（HPV）的流行情况。
Int J Environ Res Public Health. 2022 Jun 12;19(12):7213. doi: 10.3390/ijerph19127213.
4
Detection of Oral Human Papillomavirus (HPV) and its Clinical Importance.口腔人乳头瘤病毒（HPV）的检测及其临床意义
J Dent (Shiraz). 2022 Mar;23(1):51-57. doi: 10.30476/DENTJODS.2021.88338.1326.
5
Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections.预防耳鼻喉相关口腔感染的天然化合物
Plants (Basel). 2021 Sep 6;10(9):1847. doi: 10.3390/plants10091847.
6
Human papillomavirus, Epstein-Barr virus, and Candida albicans co-infection in oral leukoplakia with different degrees of dysplasia.人乳头瘤病毒、EB 病毒和白念珠菌在不同程度异型增生的口腔白斑中的合并感染。
Clin Exp Dent Res. 2021 Oct;7(5):914-923. doi: 10.1002/cre2.435. Epub 2021 Jun 8.
7
Non-invasive saliva-based screening of high-risk Human Papilloma Virus 16 and 18 in healthy young adults and creating awareness about its vaccination.对健康年轻成年人进行基于唾液的高危人乳头瘤病毒16型和18型非侵入性筛查，并提高对其疫苗接种的认识。
J Family Med Prim Care. 2021 Jan;10(1):387-391. doi: 10.4103/jfmpc.jfmpc_1669_20. Epub 2021 Jan 30.
8
Oral Human Papillomavirus: a multisite infection.口腔人乳头瘤病毒：一种多部位感染。
Med Oral Patol Oral Cir Bucal. 2020 May 1;25(3):e425-e430. doi: 10.4317/medoral.23462.
9
Prevalence of human papillomavirus (HPV) in Brazil: A systematic review and meta-analysis.巴西人乳头瘤病毒（HPV）感染的流行率：系统评价和荟萃分析。
PLoS One. 2020 Feb 21;15(2):e0229154. doi: 10.1371/journal.pone.0229154. eCollection 2020.
10
Detection of human papillomavirus DNA in formalin-fixed, paraffin-embedded squamous papillomas of the oral cavity.口腔福尔马林固定石蜡包埋鳞状乳头状瘤中人乳头瘤病毒DNA的检测
J Clin Exp Dent. 2018 Oct 1;10(10):e979-e983. doi: 10.4317/jced.55187. eCollection 2018 Oct.
本文引用的文献
1
Prevalence of human papillomavirus (HPV) in oral cavity and oropharynx.口腔和口咽中人类乳头瘤病毒（HPV）的患病率。
Braz J Otorhinolaryngol. 2006 Mar-Apr;72(2):272-82. doi: 10.1016/s1808-8694(15)30068-9.
2
Prevalence of human papillomavirus cervical infection in an Italian asymptomatic population.意大利无症状人群中人乳头瘤病毒宫颈感染的患病率
BMC Infect Dis. 2005 Sep 27;5:77. doi: 10.1186/1471-2334-5-77.
3
[Detection of human papilloma virus in cytologic samples or biopsies of the cervix].[宫颈细胞学样本或活检中人类乳头瘤病毒的检测]
Rev Med Chil. 2005 Jun;133(6):639-44. doi: 10.4067/s0034-98872005000600003. Epub 2005 Jul 22.
4
Folate is associated with the natural history of high-risk human papillomaviruses.叶酸与高危型人乳头瘤病毒的自然史相关。
Cancer Res. 2004 Dec 1;64(23):8788-93. doi: 10.1158/0008-5472.CAN-04-2402.
5
[Human papillomavirus (HPV) infection and its relation with squamous cell carcinoma of the mouth and oropharynx].[人乳头瘤病毒（HPV）感染及其与口腔和口咽鳞状细胞癌的关系]
Rev Assoc Med Bras (1992). 2004 Jul-Sep;50(3):252-6. doi: 10.1590/s0104-42302004000300029. Epub 2004 Oct 21.
6
The role of human papillomavirus in oral carcinogenesis.人乳头瘤病毒在口腔癌发生中的作用。
Crit Rev Oral Biol Med. 2004 Jul 1;15(4):188-96. doi: 10.1177/154411130401500402.
7
Relationship between smoking and human papillomavirus infections in HIV-infected and -uninfected women.感染和未感染HIV的女性中吸烟与人类乳头瘤病毒感染之间的关系。
J Infect Dis. 2004 May 15;189(10):1821-8. doi: 10.1086/383479. Epub 2004 Apr 27.
8
HPV infections and tonsillar carcinoma.人乳头瘤病毒感染与扁桃体癌
J Clin Pathol. 2004 May;57(5):449-55. doi: 10.1136/jcp.2003.008656.
9
Human papillomavirus in oral exfoliated cells and risk of head and neck cancer.口腔脱落细胞中的人乳头瘤病毒与头颈癌风险
J Natl Cancer Inst. 2004 Mar 17;96(6):449-55. doi: 10.1093/jnci/djh074.
10
Concordance of prevalence of human papillomavirus DNA in anogenital and oral infections in a high-risk population.高危人群中肛门生殖器和口腔感染人乳头瘤病毒DNA的患病率一致性
J Clin Microbiol. 2004 Mar;42(3):1330-2. doi: 10.1128/JCM.42.3.1330-1332.2004.
Zotero 插件