[人类乳头瘤病毒致癌性与HIV阳性患者肛门上皮内瘤变分级]

[Human papillomavirus oncogenicity and grade of anal intraepithelial neoplasia in HIV positive patients].

作者信息

Manzione Carmen Ruth, Nadal Sidney Roberto, Calore Edenilson Eduardo

机构信息

Seção de Patologia, Instituto de Infectologia Emilio Ribas, São Paulo, SP.

出版信息

Rev Assoc Med Bras (1992). 2004 Jul-Sep;50(3):282-5. doi: 10.1590/s0104-42302004000300035. Epub 2004 Oct 21.

DOI:10.1590/s0104-42302004000300035

PMID:15499480

Abstract

OBJECTIVE

We decided to evaluate if grade of anal intraepithelial neoplasia (AIN) was associated to the HPV type in HIV positive patients, since this group of patients has immunodeficiency over long periods. We identified HPV types by PCR (polimerase chain reaction) and histological examination to determine the AIN grade in 39 HIV positive males with anal condylomata acuminata.

RESULTS

We observed high grade AIN (HAIN) in 9 (23.1 percent) and low grade AIN (LAIN) in 30 patients (76.9 percent). The most frequent HPV types were 6 and 11 (64 percent) and oncogenic types 16, 18 and 31 appeared in 20.5 percent of patients. We could not identify viral type in four patients (10.2 percent) despite tests revealing presence of viral deoxiribonucleic acid. Comparing AIN grades with viral types we observed that non-oncogenic types can also be associated with HAIN lesions.

CONCLUSION

These results allowed us to conclude that both oncogenic and non-oncogenic HPV types can be associated with HAIN lesions in HIV positive patients.

摘要

目的

鉴于这组患者长期存在免疫缺陷，我们决定评估肛门上皮内瘤变（AIN）的分级是否与HIV阳性患者的人乳头瘤病毒（HPV）类型相关。我们通过聚合酶链反应（PCR）和组织学检查确定了39例患有肛门尖锐湿疣的HIV阳性男性患者的HPV类型及AIN分级。

结果

我们观察到9例（23.1%）患者为高级别AIN（HAIN），30例（76.9%）患者为低级别AIN（LAIN）。最常见的HPV类型为6型和11型（64%），致癌型16、18和31型出现在20.5%的患者中。尽管检测显示存在病毒脱氧核糖核酸，但仍有4例患者（10.2%）无法确定病毒类型。比较AIN分级与病毒类型，我们观察到非致癌型HPV也可与HAIN病变相关。