Pacanowski Jerome, Develioglu Leyla, Kamga Isabelle, Sinet Martine, Desvarieux Moïse, Girard Pierre-Marie, Hosmalin Anne
Département de Maladies Infectieuses et Tropicales, Hôpital St. Antoine, Assistance Publique--Hopitaux de Paris, Universite Paris VI, Paris, France.
J Infect Dis. 2004 Nov 15;190(10):1889-92. doi: 10.1086/425020. Epub 2004 Oct 18.
During human immunodeficiency virus (HIV) infection, interruption of highly active antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here, the number of pDCs was measured by flow cytometry before, during, and after receipt of HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was evidenced between pDC counts after 1 month of HAART and mean plasma virus load after interruption of HAART (r2=0.85; Spearman's partial rho =-0.92; P=.03). pDC counts during treatment might help predict immune replication control after interruption of HAART.
在人类免疫缺陷病毒（HIV）感染期间，高效抗逆转录病毒疗法（HAART）中断后通常会出现病毒载量反弹。先前的数据表明浆细胞样树突状细胞（pDCs）在抗HIV固有免疫中发挥作用。在此，通过流式细胞术对7例确诊为原发性HIV-1感染的患者在接受HAART之前、期间和之后的pDC数量进行了测量。HAART治疗1个月后的pDC计数与HAART中断后的平均血浆病毒载量之间存在负相关（r2 = 0.85；Spearman偏相关系数=-0.92；P = 0.03）。治疗期间的pDC计数可能有助于预测HAART中断后的免疫复制控制情况。
