Prescrire Int. 2004 Oct;13(73):186.
(1) Topiramate carries a dose-dependent risk of severe metabolic acidosis in adults and children. (2) Various situations increase the risk, including diarrhea, respiratory disorders and surgery. (3) Loss of appetite, fatigue and hyperventilation are warning signs.
(1) 托吡酯在成人和儿童中存在剂量依赖性的严重代谢性酸中毒风险。(2) 多种情况会增加这种风险，包括腹泻、呼吸系统疾病和手术。(3) 食欲不振、疲劳和呼吸急促是警示信号。
