Tomaru T, Geschwind H J, Boussignac G, Lange F, Tahk S J
Exploration Fonctionnelles, Henri Mondor Hospital, Paris University XII, Créteil, France.
Am Heart J. 1992 Apr;123(4 Pt 1):896-904. doi: 10.1016/0002-8703(92)90693-p.
Shock waves were investigated using an excimer laser at 308 nm with 18.9 mjoules/pulse, a pulsed dye laser at 480 nm with 100 mjoules/pulse, and a holmium YAG (yttrium-aluminum-garnet) laser at 2.1 microns with 420 mjoules/pulse. At a distance from the target tissue, excimer lasing resulted in no shock waves in saline, while the other lasers produced smaller shock waves than those recorded when the laser was in contact with tissue (0.22 versus 2.0 mm Hg with the pulsed dye laser, 0 versus 0.23 mm Hg with the excimer laser, and 0.44 versus 6.9 mm Hg with the holmium YAG laser; p less than 0.001, respectively). In blood, excimer laser irradiation at a distance from the tissue produced shock waves as great as those produced when the laser was in contact with the tissue (0.19 versus 0.24 mm Hg with the excimer laser, 1.8 versus 3.0 mm Hg with the pulsed dye laser, and 3.1 versus 5.9 mm Hg with the holmium YAG laser; p less than 0.001 with the pulsed dye and holmium YAG lasers, respectively). When lasing was done at 60 mjoules/mm2, the pulsed dye and excimer lasers produced similar shock waves when the lasers were in contact with tissue; however, the holmium YAG laser did not produce shock waves. Thus pulsed lasers can produce shock waves of different characteristics according to the laser source.
使用波长为308nm、能量为18.9毫焦/脉冲的准分子激光、波长为480nm、能量为100毫焦/脉冲的脉冲染料激光以及波长为2.1微米、能量为420毫焦/脉冲的钬钇铝石榴石（Ho:YAG）激光来研究冲击波。在距靶组织一定距离处，准分子激光在盐水中未产生冲击波，而其他激光产生的冲击波比激光与组织接触时记录到的要小（脉冲染料激光分别为0.22对2.0mmHg，准分子激光为0对0.23mmHg，钬钇铝石榴石激光为0.44对6.9mmHg；p均小于0.001）。在血液中，距组织一定距离处的准分子激光照射产生的冲击波与激光与组织接触时产生的一样大（准分子激光分别为0.19对0.24mmHg，脉冲染料激光为1.8对3.0mmHg，钬钇铝石榴石激光为3.1对5.9mmHg；脉冲染料激光和钬钇铝石榴石激光的p分别小于0.001）。当以60毫焦/平方毫米的能量进行激光照射时，脉冲染料激光和准分子激光与组织接触时产生的冲击波相似；然而，钬钇铝石榴石激光未产生冲击波。因此，脉冲激光可根据激光源产生不同特性的冲击波。
