Mitarai Tetsuya
Department of Internal Medicine, Saitama Medical Center, Saitama Medical School.
Nihon Rinsho. 2004 Oct;62(10):1893-7.
Nephrotic syndrome is defined as the glomerular disease with massive proteinuria and hypoalbuminemia, and complications are numerous. Among these complications, saltwater retention, thromboembolism, hyperlipidemia, metabolic bone disease, infections are important for management of nephrotic syndrome. Recent advances in the understanding of alterations in the metabolism of circulating and somatic proteins associated with proteinuria and hypooncotic condition have led to new insights into the pathophysiologic processes associated with this syndrome. Therapeutic consideration should be paid not only for the treatment of primary diseases, but also for the prevention of these complications.
肾病综合征被定义为伴有大量蛋白尿和低白蛋白血症的肾小球疾病，且并发症众多。在这些并发症中，水钠潴留、血栓栓塞、高脂血症、代谢性骨病、感染对于肾病综合征的管理很重要。最近对与蛋白尿和低蛋白血症相关的循环和体细胞蛋白质代谢改变的认识进展，为该综合征相关的病理生理过程带来了新的见解。治疗时不仅应考虑原发性疾病的治疗，还应考虑这些并发症的预防。
