Shalak Lina, Perlman Jeffrey M
Department of Pediatrics, Southwestern Medical Center, University of Texas, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Early Hum Dev. 2004 Nov;80(2):125-41. doi: 10.1016/j.earlhumdev.2004.06.003.
An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.
对分娩期缺氧缺血后导致持续性脑损伤的细胞特征有了更深入的了解，从而在新生儿期实施了有针对性的神经保护策略。本综述简要介绍了缺氧缺血性损伤的发病机制，重点是再灌注损伤；磁共振成像在检测此类损伤中的作用，并着重探讨了支持性和神经保护性的潜在策略，以预防持续性损伤，特别强调了适度低温。
