2,3,5-三甲基苯并[b]噻吩系列二芳基胺的抗菌活性筛选：一项构效关系评估研究。
Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure-activity evaluation study.
作者信息
Ferreira Isabel C F R, Calhelha Ricardo C, Estevinho Letícia M, Queiroz Maria-João R P
机构信息
Escola Superior Agrária, Instituto Politécnico de Bragança, Campus de Sta. Apolónia, Apartado 1172, 5301-854 Bragança, Portugal.
出版信息
Bioorg Med Chem Lett. 2004 Dec 6;14(23):5831-3. doi: 10.1016/j.bmcl.2004.09.038.
Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C-N coupling methodology. The minimal inhibitory concentration (MIC) and structure-activity relationships (SARs) were evaluated.
革兰氏阳性菌（蜡样芽孢杆菌、枯草芽孢杆菌）、革兰氏阴性菌（铜绿假单胞菌、大肠杆菌）以及作为真菌代表的白色念珠菌，被用于筛选我们采用钯催化C-N偶联方法合成的、带有不同取代基的2,3,5-三甲基苯并[b]噻吩系列二芳基胺的体外抗菌活性。评估了最低抑菌浓度（MIC）和构效关系（SARs）。
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