脑室内注射神经肽EI可增加雄性和雌性大鼠的血清促黄体生成素。

Intracerebroventricular injection of neuropeptide EI increases serum LH in male and female rats.

作者信息

Attademo Andrés M, Sánchez-Borzone Mariela, Lasaga Mercedes, Celis Maria Ester

机构信息

Laboratorio de Ciencias Fisiológicas, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional de Córdoba, Córdoba CP5000, Argentina.

出版信息

Peptides. 2004 Nov;25(11):1995-9. doi: 10.1016/j.peptides.2004.06.010.

DOI:10.1016/j.peptides.2004.06.010

PMID:15501532

Abstract

Melanin concentrating hormone (MCH) precursor-derived neuropeptide EI (NEI) has not yet been extensively studied. The aim of this study was to determine the effect of neuropeptide EI on serum levels of LH in normal male rats and chronically ovariectomized (CHR-OVX) female rats treated with estrogen benzoate (EB) and with a low dose of progesterone. The peptide, administered intracerebroventricularly in male and chronically ovariectomized female rats, increased LH serum levels compared to the controls injected with artificial cerebrospinal fluid. It is important to note that there is some relation between neuropeptide EI-melanin concentrating hormone and alpha-melanocyte stimulating hormone (alpha-MSH) indicating that all three peptides are associated in a complex inter-relationship. Therefore, the question that arises is if neuropeptide EI could also be related with the receptors for melanin concentrating hormone or alpha-melanocyte stimulating hormone.

摘要

源自黑色素聚集激素（MCH）前体的神经肽EI（NEI）尚未得到广泛研究。本研究的目的是确定神经肽EI对正常雄性大鼠以及用苯甲酸雌二醇（EB）和低剂量孕酮处理的慢性卵巢切除（CHR-OVX）雌性大鼠血清促黄体生成素（LH）水平的影响。在雄性和慢性卵巢切除的雌性大鼠中脑室内注射该肽后，与注射人工脑脊液的对照组相比，血清LH水平升高。需要注意的是，神经肽EI - 黑色素聚集激素与α-黑素细胞刺激素（α-MSH）之间存在某种关系，这表明所有这三种肽都以复杂的相互关系相互关联。因此，出现的问题是神经肽EI是否也可能与黑色素聚集激素或α-黑素细胞刺激素的受体有关。