Tran Stefanie E F, Meinander Annika, Eriksson John E
Institut de Génétique Moléculaire et Cellulaire de Montpellier, CNRS UMR 5535, 1919 route de Mende, 34293 Montpellier, France.
Trends Biochem Sci. 2004 Nov;29(11):601-8. doi: 10.1016/j.tibs.2004.09.009.
Transcription-independent modulation of signaling mediated by death receptors (DRs) has emerged as an important determinant of cell survival during both development and cellular homeostasis. Frequently, a given DR signal must be redirected rapidly either to inhibit or to potentiate the apoptotic response. This process requires immediate, protein-synthesis-independent modifications of the regulatory molecules involved. Numerous mechanisms have been shown to regulate DR responses without engaging the apoptosis-directing transcription machinery. These mechanisms involve key posttranslational modifications such as phosphorylation, ubiquitination and proteolytic degradation, all of which affect the activities of proteins at different levels in the DR signaling pathways. Changes in the organization of regulatory molecules and in their interactions with other factors also affect the DR signaling pathways. The balance between these modulatory signals rapidly decides the fate of a cell.
由死亡受体（DRs）介导的信号传导的转录非依赖性调节已成为发育和细胞稳态过程中细胞存活的重要决定因素。通常，给定的DR信号必须迅速重新定向，以抑制或增强凋亡反应。这个过程需要对相关调节分子进行即时的、不依赖蛋白质合成的修饰。已证明许多机制可在不涉及凋亡指导转录机制的情况下调节DR反应。这些机制涉及关键的翻译后修饰，如磷酸化、泛素化和蛋白水解降解，所有这些修饰都在不同水平上影响DR信号通路中蛋白质的活性。调节分子组织的变化及其与其他因子的相互作用也会影响DR信号通路。这些调节信号之间的平衡迅速决定细胞的命运。
