Gepdiremen A, Aydin N, Halici Z, S Ahin O, Unal B, Aydin M D, Bakuridze K
Department of Pharmacology, Medical Faculty, Atatürk University, TR-25240 Erzurum, Turkey.
Pharmacol Res. 2004 Dec;50(6):569-74. doi: 10.1016/j.phrs.2004.06.003.
Haloperidol is a widely used antipsychotic drug, which exerts its effects via antagonizing the dopaminergic D2 receptors. Also it affects a number of receptors on vascular bed and other tissues. The impact of haloperidol on vascular bed seems still debatable and not clear. In the present study, haloperidol was given to adult rats in 0.5, 1, 2.5 and 5 mg kg(-1) doses, once a day, intraperitoneally in 1 ml volumes, for 9 weeks. After decapitation under Pentothal anesthesia, brains and basilar arteries were dissected out at midpontine level immediately. Conventional histopathology and morphometric analysis were carried out on the dissected artery branches. Medial and adventitial layers, endothelial cells and internal elastic membranes were observed as normal in the control group. It was determined clearly that the lumen of basilar artery in the control group was larger than in the other groups and also it was observed that is more regular the lumen contours of basilar artery in control group compared with other groups. Finally, wall thickness of basilar artery in all experimental groups decreased significantly due to the vasoconstriction. Regarding the total, lumen and wall volumes, 1 mg kg(-1) haloperidol induces vasoconstriction more than the other groups.
氟哌啶醇是一种广泛使用的抗精神病药物，它通过拮抗多巴胺能D2受体发挥作用。此外，它还会影响血管床和其他组织上的多种受体。氟哌啶醇对血管床的影响似乎仍存在争议且尚不明确。在本研究中，以0.5、1、2.5和5 mg·kg⁻¹的剂量给成年大鼠腹腔注射氟哌啶醇，每天一次，注射体积为1 ml，持续9周。在硫喷妥钠麻醉下断头后，立即在脑桥中部水平取出大脑和基底动脉。对取出的动脉分支进行常规组织病理学和形态计量学分析。对照组的中膜和外膜层、内皮细胞和内弹性膜观察正常。明确测定出对照组基底动脉的管腔比其他组大，并且还观察到与其他组相比，对照组基底动脉的管腔轮廓更规则。最后，由于血管收缩，所有实验组基底动脉的壁厚度均显著降低。总体而言，1 mg·kg⁻¹氟哌啶醇比其他组更易引起血管收缩。
