志贺毒素与分离出的猪组织及外周血白细胞的结合。
Shiga toxin binding to isolated porcine tissues and peripheral blood leukocytes.
作者信息
Winter Kellie R K, Stoffregen William C, Dean-Nystrom Evelyn A
机构信息
Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, USDA Agricultural Research Service, National Animal Disease Center, Ames 50010-0070, USA.
出版信息
Infect Immun. 2004 Nov;72(11):6680-4. doi: 10.1128/IAI.72.11.6680-6684.2004.
Abstract
Shiga toxin (Stx) binding sites in porcine tissues and leukocytes were identified by the use of Stx overlay and anti-CD77/Gb3 immunoassays. Stx1 and Stx2 bound to similar tissue locations and leukocytes, although some differences were noted. Previously unreported Stx binding sites were identified in kidney tubules, intestinal lymphoid aggregates, sinusoidal liver cells, alveolar macrophages, and peripheral blood leukocytes.
摘要
通过使用志贺毒素（Stx）覆盖法和抗CD77/GB3免疫测定法，确定了猪组织和白细胞中的志贺毒素（Stx）结合位点。尽管存在一些差异，但Stx1和Stx2与相似的组织位置和白细胞结合。在肾小管、肠道淋巴集结、肝血窦细胞、肺泡巨噬细胞和外周血白细胞中发现了以前未报道的Stx结合位点。
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