University of Maryland School of Medicine, Baltimore, MD 21201.
Microbiol Spectr. 2014 Jun;2(3). doi: 10.1128/microbiolspec.EHEC-0005-2013.
Shiga toxin (Stx) is the primary cause of severe host responses including renal and central nervous system (CNS) disease in Shiga toxin-producing E. coli (STEC) infections. The interaction of Stx with different eukaryotic cell types is described. Host responses to Stx and bacterial lipopolysaccharide (LPS) are compared as related to the features of the STEC-associated Hemolytic Uremic Syndrome (HUS). Data derived from animal models of HUS and CNS disease, in vivo, and eukaryotic cells, in vitro, are evaluated in relation to HUS disease of humans.
志贺毒素（Stx）是产志贺毒素大肠杆菌（STEC）感染中引起严重宿主反应的主要原因，包括肾脏和中枢神经系统（CNS）疾病。本文描述了 Stx 与不同真核细胞类型的相互作用。比较了宿主对 Stx 和细菌脂多糖（LPS）的反应，以了解与 STEC 相关的溶血性尿毒症综合征（HUS）的特征。评估了来自 HUS 动物模型、体内真核细胞和体外实验的数据与人类 HUS 疾病的关系。
