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本文引用的文献

1
Virulence properties of Streptococcus mutans.变形链球菌的毒力特性。
Front Biosci. 2004 May 1;9:1267-77. doi: 10.2741/1305.
2
Role of the C-terminal lysine residues of streptococcal surface enolase in Glu- and Lys-plasminogen-binding activities of group A streptococci.A群链球菌表面烯醇化酶C末端赖氨酸残基在Glu-和Lys-纤溶酶原结合活性中的作用
Infect Immun. 2004 Jan;72(1):94-105. doi: 10.1128/IAI.72.1.94-105.2004.
3
Enolase from Streptococcus sobrinus is an immunosuppressive protein.来自远缘链球菌的烯醇化酶是一种免疫抑制蛋白。
Cell Microbiol. 2004 Jan;6(1):79-88. doi: 10.1046/j.1462-5822.2003.00344.x.
4
MG2 and lactoferrin form a heterotypic complex in salivary secretions.MG2和乳铁蛋白在唾液分泌物中形成异型复合物。
J Dent Res. 2003 Jun;82(6):471-5. doi: 10.1177/154405910308200613.
5
Molecular diagnosis of infective endocarditis by PCR amplification and direct sequencing of DNA from valve tissue.通过对瓣膜组织DNA进行PCR扩增和直接测序对感染性心内膜炎进行分子诊断。
J Clin Microbiol. 2003 Feb;41(2):763-6. doi: 10.1128/JCM.41.2.763-766.2003.
6
Interaction of human salivary mucin MG2, its recombinant N-terminal region and a synthetic peptide with Actinobacillus actinomycetemcomitans.人唾液粘蛋白MG2、其重组N端区域及一种合成肽与伴放线放线杆菌的相互作用
J Periodontal Res. 2002 Dec;37(6):416-24. doi: 10.1034/j.1600-0765.2002.01005.x.
7
Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen.变形链球菌UA159的基因组序列，一种致龋性口腔病原体。
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14434-9. doi: 10.1073/pnas.172501299. Epub 2002 Oct 23.
8
Analysis of Streptococcus mutans proteins modulated by culture under acidic conditions.变形链球菌在酸性条件下培养所调控蛋白质的分析
Appl Environ Microbiol. 2002 May;68(5):2382-90. doi: 10.1128/AEM.68.5.2382-2390.2002.
9
Identification of major outer surface proteins of Streptococcus agalactiae.无乳链球菌主要外表面蛋白的鉴定
Infect Immun. 2002 Mar;70(3):1254-9. doi: 10.1128/IAI.70.3.1254-1259.2002.
10
Multifunctional alpha-enolase: its role in diseases.多功能α-烯醇化酶：其在疾病中的作用。
Cell Mol Life Sci. 2001 Jun;58(7):902-20. doi: 10.1007/pl00000910.

变形链球菌表面α-烯醇化酶结合唾液粘蛋白MG2和人纤溶酶原。

Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen.

作者信息

Ge Jingping, Catt Diana M, Gregory Richard L

机构信息

Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, USA.

出版信息

Infect Immun. 2004 Nov;72(11):6748-52. doi: 10.1128/IAI.72.11.6748-6752.2004.

DOI:10.1128/IAI.72.11.6748-6752.2004
PMID:15501816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC523000/
Abstract

Matrix-assisted laser desorption ionization-time of flight mass spectrometry analysis identified enolase as a cell surface component of Streptococcus mutans, which was confirmed by enzyme-linked immunosorbent assay, Western blotting, and transmission electron microscopy. Surface enolase was demonstrated to bind to human plasminogen and salivary mucin MG2. The results suggested a role for enolase in S. mutans attachment, clearance, or breach of the bloodstream barrier.

摘要

基质辅助激光解吸电离飞行时间质谱分析确定烯醇化酶是变形链球菌的一种细胞表面成分，这通过酶联免疫吸附测定、蛋白质印迹法和透射电子显微镜得到了证实。表面烯醇化酶被证明能与人纤溶酶原和唾液粘蛋白MG2结合。结果表明烯醇化酶在变形链球菌附着、清除或突破血流屏障中发挥作用。