Issa Elio, Salloum Tamara, Tokajian Sima
Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon.
Front Microbiol. 2020 May 7;11:826. doi: 10.3389/fmicb.2020.00826. eCollection 2020.
is a β-hemolytic Gram-positive member of the group (SAG). Despite being a part of the normal microbiota, it is one of the most common pathogens associated with brain and liver abscesses and thoracic empyema, increasing as a result the morbidity and mortality rates in affected patients. Though there are numerous published case reports on infections, it is still understudied compared to other SAG members. Our knowledge of the genomic factors contributing to its dissemination to the brain and abscess development is also limited to few characterized genes. In this review, we summarize our current knowledge on identification methods, virulence factors, and insight provided by the whole-genome and correlate patients' metadata, symptoms, and disease outcome with infections in 101 recent case reports obtained from PubMed. This combined information highlights the gaps in our understanding of pathogenesis, suggesting future research directions to unveil the factors contributing to abscess development.
是链球菌属（SAG）的一种β溶血性革兰氏阳性菌。尽管它是正常微生物群的一部分，但它是与脑和肝脓肿以及胸腔积脓相关的最常见病原体之一，从而增加了受影响患者的发病率和死亡率。虽然有许多关于该菌感染的已发表病例报告，但与其他SAG成员相比，对其研究仍较少。我们对导致其传播至脑部和脓肿形成的基因组因素的了解也仅限于少数已鉴定的基因。在本综述中，我们总结了目前关于该菌鉴定方法、毒力因子的知识，以及全基因组提供的见解，并将101篇近期从PubMed获取的病例报告中患者的元数据、症状和疾病结局与该菌感染相关联。这些综合信息凸显了我们对该菌发病机制理解上的差距，为揭示导致脓肿形成的因素指明了未来的研究方向。
