Cohn William E
Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Texas 77225, USA.
Curr Opin Cardiol. 2004 Nov;19(6):589-92. doi: 10.1097/01.hco.0000142472.04595.e5.
The high prevalence of coronary artery disease (CAD) has inspired the development of technologies and techniques for coronary revascularization, including coronary artery bypass grafting (CABG) and catheter-based interventions (CBIs).
Although CBIs allow the avoidance of general anesthesia, sternotomy, and cardiopulmonary bypass, CBIs-including those performed using drug-eluting stents-are associated with much higher rates of vascular reocclusion than is CABG. In addition, CBIs are not well suited to patients with diabetes or chronic total occlusion, both of which are extremely common in the CAD population. In contrast, CABG has proven effective for CAD patients with these conditions. The technology used in CABG continues to improve; ongoing innovations include off-pump coronary artery bypass; gene therapy to prevent restenosis; and endoscopic, video-assisted, and robot-assisted CABG using automated one-shot distal anastomotic devices.
Although CBIs for CAD are now performed more often than surgical procedures, surgery remains an important treatment option.
冠状动脉疾病(CAD)的高患病率推动了冠状动脉血运重建技术的发展,包括冠状动脉旁路移植术(CABG)和基于导管的介入治疗(CBI)。
尽管CBI可避免全身麻醉、胸骨切开术和体外循环,但包括使用药物洗脱支架进行的CBI与血管再闭塞率远高于CABG相关。此外,CBI不太适合糖尿病或慢性完全闭塞患者,这两种情况在CAD人群中极为常见。相比之下,CABG已被证明对患有这些病症的CAD患者有效。CABG中使用的技术不断改进;正在进行的创新包括非体外循环冠状动脉旁路移植术;预防再狭窄的基因治疗;以及使用自动一次性远端吻合装置的内镜、视频辅助和机器人辅助CABG。
尽管目前CAD的CBI比外科手术更常进行,但手术仍然是一种重要的治疗选择。