Kim L G, Scott R A P, Thompson S G, Collin J, Morris G E, Sutton G L, Wilson N M
Medical Research Council Biostatistics Unit, Cambridge, UK.
Br J Surg. 2005 Feb;92(2):171-6. doi: 10.1002/bjs.4807.
The Multicentre Aneurysm Screening Study (MASS) provided strong evidence for both the clinical benefit and the cost-effectiveness of a screening programme for abdominal aortic aneurysms (AAAs) in men. If a national screening programme for AAA were adopted in the UK, it would be expected to increase the elective and decrease the emergency surgical workload.
The MASS trial randomized 67,800 men aged 65-74 years to be invited to attend for ultrasonographic screening for AAA or to a control group that received no invitation. Predictions of elective and emergency surgical workload were made for a 20-year interval after the introduction of a screening programme for 65-year-old men, based on surgical rates observed in the MASS trial and national mortality statistics.
For a district general hospital serving a population of 400,000, there was an estimated reduction from nine emergency operations per year before introduction of the screening programme to three emergency operations annually in men aged 65 years and over by the end of the 20-year interval, and an increase from 24 to 43 AAA operations overall. The corresponding estimated annual costs for all AAA surgery increased by 47 per cent, from pound 209,000 to pound 308,000. These results were not affected by changes in the underlying assumptions.
The results support the expectation of very few emergency operations, and principally elective operations, being performed following the introduction of a screening programme. For a typical district general hospital, a screening programme would be expected to lead to two additional elective AAA operations per month, and to save 11 AAA-related deaths per year.
多中心动脉瘤筛查研究(MASS)为男性腹主动脉瘤(AAA)筛查项目的临床益处和成本效益提供了有力证据。如果英国采用全国性的AAA筛查项目,预计将增加择期手术量并减少急诊手术量。
MASS试验将67800名65 - 74岁的男性随机分为两组,一组被邀请参加AAA超声筛查,另一组为未收到邀请的对照组。根据MASS试验中观察到的手术率和全国死亡率统计数据,对针对65岁男性引入筛查项目后的20年期间的择期和急诊手术量进行了预测。
对于一家服务人口为40万的地区综合医院,预计在引入筛查项目前,每年有9例急诊手术,到20年期限结束时,65岁及以上男性的急诊手术量将降至每年3例,而AAA手术总量将从24例增加到43例。所有AAA手术的相应估计年度成本增加了47%,从20.9万英镑增至30.8万英镑。这些结果不受基本假设变化影响。
结果支持了引入筛查项目后急诊手术极少、主要为择期手术这一预期。对于一家典型的地区综合医院,筛查项目预计每月将额外增加2例AAA择期手术,并每年挽救11例与AAA相关的死亡病例。